منابع مشابه
Signal transduction by tumour necrosis factor and tumour necrosis factor related ligands and their receptors.
Many biological functions are regulated through interactions of extracellular molecules with their cognate cell surface receptors. The transduction of these signals by their receptors at the plasma membrane to the intracellular machinery results in such cellular activities as gene activation, protein phosphorylation, cell proliferation, and cell destruction. Though the kinetics of these activit...
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Acute Gram-negative bacterial infections evoke characteristic pathophysiological responses, including changes in white blood cell counts, fever, haemodynamic disorders, and various coagulatory disturbances, which may result in respiratory distress syndrome, multiorgan failure and irreversible shock. It is generally accepted that endotoxins, the lipopolysaccharides (LPS) of Gramnegative bacteria...
متن کاملTumour necrosis factor haplotypes and asthma.
Airway inflammation is a prominent feature of asthma. The pro-inflammatory cytokine Tumour Necrosis Factor shows constitutional variation in its level of secretion, which is linked to polymorphisms within the TNF gene complex and the surrounding MHC. In this study, 413 subjects in 88 nuclear families from a general population sample were examined for association with asthma and TNF polymorphism...
متن کاملTumour necrosis factor and Crohn's disease.
The production of several pro-inflammatory cytokines is increased in inflammatory bowel diseases (IBD). Experimental models of IBD have further defined the importance of specific cytokines for the induction of mucosal inflammation, by using specific neutralising antibodies, or by silencing cytokine genes in mice by using homologous recombination (knockout mice).' 2 Several therapeutic strategie...
متن کاملTumour necrosis factor-α in nasal allergy
Tumour necrosis factor-alpha (TNF-alpha) was measured by enzyme-linked immunosorbent assay and eosinophil cationic protein (ECP) by radio-immunoassay to evaluate TNF-alpha in nasal allergy. There was no significant difference either between the mean concentrations of TNF-alpha in nasal secretions from the patients with perennial nasal allergy and those of normal subjects, or between the TNF-alp...
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ژورنال
عنوان ژورنال: The Journal of Pathology
سال: 2013
ISSN: 0022-3417
DOI: 10.1002/path.4188